Microfibrillar structure of type I collagen in situ

Microfibrillar structure of type I collagen in situ.

The fibrous collagens are ubiquitous in animals and form the structural basis of all mammalian connective tissues, including those of the heart, vasculature, skin, cornea, bones, and tendons. However, in comparison with what is known of their production, turnover and physiological structure, very little is understood regarding the three-dimensional arrangement of collagen molecules in naturally...

Comment on Microfibrillar structure of type I collagen in situ by Orgel et al. (2006), Proc. Natl Acad. Sci. USA, 103, 9001-9005

Microfibrillar collagen model of canine cerebral infarction.

A new canine model of focal cerebral ischemia has been developed employing intravascular delivery of microfibrillar collagen via femoral catheterization. In 13 dogs, dose-effect studies showed neurologic deficits (ranging from mild hemiparesis to death) related to the dose of microfibrillar collagen delivered. In another 10 dogs, 0.5 ml of 60 mg/ml microfibrillar collagen was injected into the ...

New Insights into Structure and Function of Type I Collagen

Microfibrillar elements in the synovial joint: presence of type VI collagen and fibrillin-containing microfibrils.

OBJECTIVES The aims were to isolate and positively identify the microfibrillar elements which have been observed in the synovial lining. In addition, synovial fluid was examined for these elements to improve the understanding of the role of these structures in health and disease. METHODS Bacterial collagenase digestion of bovine synovial linings and human and bovine synovial fluids was used t...